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PureTech Health PLC
PureTech Health Plc engages in the provision of differentiated medicines for devastating diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders. The company is headquartered in Boston, Massachusetts and currently employs 66 full-time employees. The company went IPO on 2015-06-19. The firm is engaged in discovering, developing and commercializing medicines for diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders. The firm's wholly owned pipeline consists of six therapeutic candidates including LYT-100 (deupirfenidone), LYT-200, LYT-210, LYT-300 (oral allopregnanolone), LYT-500, and LYT-503/IMB-150. Its segments include Internal, Controlled Founded Entity, Non-Controlled Founded Entities, and Parent Company and Other. Its Internal segment is advancing wholly owned programs designed to harness immunological, fibrotic and lymphatic system mechanisms. These classes of immunomodulatory drugs are designed to treat serious diseases, including lung dysfunction, immuno-oncology, lymphatic, neurological and neuropsychological disorders.
PureTech Health Plc engages in the provision of differentiated medicines for devastating diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders. The company is headquartered in Boston, Massachusetts and currently employs 66 full-time employees. The company went IPO on 2015-06-19. The firm is engaged in discovering, developing and commercializing medicines for diseases, including inflammatory, fibrotic and immunological conditions, intractable cancers, lymphatic and gastrointestinal diseases and neurological and neuropsychological disorders. The firm's wholly owned pipeline consists of six therapeutic candidates including LYT-100 (deupirfenidone), LYT-200, LYT-210, LYT-300 (oral allopregnanolone), LYT-500, and LYT-503/IMB-150. Its segments include Internal, Controlled Founded Entity, Non-Controlled Founded Entities, and Parent Company and Other. Its Internal segment is advancing wholly owned programs designed to harness immunological, fibrotic and lymphatic system mechanisms. These classes of immunomodulatory drugs are designed to treat serious diseases, including lung dysfunction, immuno-oncology, lymphatic, neurological and neuropsychological disorders.
Strong Balance Sheet: PureTech ended the half year with just under $320 million in cash, giving the company operational runway well into 2028 without needing to raise external capital.
Focused Portfolio: The company is now concentrating on three core entities—Seaport Therapeutics, Gallop Oncology, and Celea Therapeutics—which are expected to drive future growth and value.
Reduced Costs: Operating expenses dropped to just under $50 million in the first half of 2025 from $66.7 million a year earlier, mainly due to the spinout of Seaport and ongoing efforts to further reduce R&D and G&A costs.
External Funding Strategy: PureTech is using a hub-and-spoke model to seek external capital for Celea and Gallop, which is expected to further lower PureTech’s cash burn and extend its cash runway.
Pipeline Progress: Celea’s lead program, deupirfenidone, showed promising Phase IIb results in IPF patients, with plans for a Phase III trial initiation in the first half of 2026 pending FDA alignment.
Royalty Upside: PureTech expects around $300 million over time from Cobenfy royalties and milestones based on consensus analyst forecasts, with additional upside possible if label expansions succeed.
Active Partnering and Spinouts: Gallop Oncology and Celea Therapeutics are progressing towards external funding, and PureTech retains full ownership in both until these deals close.
