Allogene Therapeutics Inc
NASDAQ:ALLO
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Allogene Therapeutics Inc
Allogene Therapeutics, Inc. operates as a clinical stage immuno-oncology company pioneering the development and commercialization of genetically engineered allogeneic T cell therapies for the treatment of cancer. The company is headquartered in South San Francisco, California and currently employs 310 full-time employees. The company went IPO on 2018-10-11. The firm is focused on the development and commercialization of genetically engineered allogeneic T cell therapies for the treatment of cancer. The company is engaged in developing a pipeline of multiple allogeneic chimeric antigen receptor (CAR) T cell product candidates utilizing protein engineering, gene editing, gene insertion and advanced T cell manufacturing technologies. Its advanced product candidates, ALLO-501 and ALLO-501A, are engineered allogeneic CAR T cell therapies that target CD19, a protein expressed on the cell surface of B cells and a validated target for B cell driven hematological malignancies. The company is also developing engineered allogeneic CAR T cell product candidates for multiple myeloma, clear cell renal cell carcinoma (ccRCC), and other blood cancers and solid tumors. Its lead product candidates include ALLO-501, ALLO-501A, ALLO-715, ALLO-715 plus nirogacestat, ALLO-605, ALLO-316, and ALLO-647.
Allogene Therapeutics, Inc. operates as a clinical stage immuno-oncology company pioneering the development and commercialization of genetically engineered allogeneic T cell therapies for the treatment of cancer. The company is headquartered in South San Francisco, California and currently employs 310 full-time employees. The company went IPO on 2018-10-11. The firm is focused on the development and commercialization of genetically engineered allogeneic T cell therapies for the treatment of cancer. The company is engaged in developing a pipeline of multiple allogeneic chimeric antigen receptor (CAR) T cell product candidates utilizing protein engineering, gene editing, gene insertion and advanced T cell manufacturing technologies. Its advanced product candidates, ALLO-501 and ALLO-501A, are engineered allogeneic CAR T cell therapies that target CD19, a protein expressed on the cell surface of B cells and a validated target for B cell driven hematological malignancies. The company is also developing engineered allogeneic CAR T cell product candidates for multiple myeloma, clear cell renal cell carcinoma (ccRCC), and other blood cancers and solid tumors. Its lead product candidates include ALLO-501, ALLO-501A, ALLO-715, ALLO-715 plus nirogacestat, ALLO-605, ALLO-316, and ALLO-647.
Pivotal Data Milestones: Allogene expects interim data from the pivotal ALPHA3 trial in lymphoma and proof-of-concept results from the ALLO-329 autoimmune program in the first half of 2026.
Financial Position: The company ended Q3 2025 with $277.1 million in cash, supporting a runway into the second half of 2027.
Clinical Progress: ALPHA3 has over 50 active sites open for enrollment, and the transition to a 2-arm trial has slightly increased patient screening.
Key Efficacy Benchmark: A 30% MRD conversion delta is considered a significant win for cema-cel in ALPHA3, much greater than reference studies in lymphoma and bladder cancer.
Autoimmune Program: Early data for ALLO-329 will include both biomarkers and initial clinical responses in a handful of patients, with broader indication potential discussed.
Cost Discipline: Allogene reaffirmed 2025 cash burn guidance of about $150 million and full-year operating expenses of about $230 million.
Regulatory Outlook: Ongoing FDA communications remain productive, and management sees the potential for flexible approval pathways for CAR-T therapies.
