Alnylam Pharmaceuticals Inc
NASDAQ:ALNY

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Alnylam Pharmaceuticals Inc Logo
Alnylam Pharmaceuticals Inc
NASDAQ:ALNY
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Price: 430.02 USD -6.13% Market Closed
Market Cap: 56.8B USD

Alnylam Pharmaceuticals Inc
Investor Relations

In the heart of the biotechnology revolution, Alnylam Pharmaceuticals Inc. has been a pioneering force, transforming the landscape of medicine through its innovative use of RNA interference (RNAi) technology. Founded in 2002 and based in Cambridge, Massachusetts, the company set out on a bold mission to silence disease-causing genes by targeting RNA, the intermediary that carries genetic instructions necessary for protein synthesis. This groundbreaking approach diverges from traditional methods that focus on targeting proteins directly and instead intervenes earlier in the disease process to eliminate or reduce the proteins before they can wreak havoc on the body. Fueled by extensive research and a robust pipeline, Alnylam has successfully brought several RNAi-based therapies to market, such as Onpattro and Givlaari, which address rare genetic disorders with high unmet medical needs.

Alnylam's business model is centered around the commercial success of its novel therapies, partnerships with other pharmaceutical giants, and strategic collaborations for global distribution. By securing alliances with industry leaders like Sanofi and Regeneron, Alnylam has been able to expand its research capabilities and broaden its market reach. Revenue for the company is primarily driven by the sales of its approved products, which continue to grow as they gain acceptance within the medical community. Additionally, Alnylam's extensive patent portfolio and its strategic licensing agreements provide an additional revenue stream, safeguarding its innovations and ensuring it retains a competitive edge in this rapidly advancing field. Through its relentless pursuit of innovation, Alnylam continues to position itself as a trailblazer in turning the once theoretical promise of RNAi into a clinical reality.

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Last Earnings Call
Fiscal Period
Q3 2025
Call Date
Oct 30, 2025
AI Summary
Q3 2025

Top-line Beat: Alnylam reported Q3 total net product revenue of $851 million, up 103% year-over-year and 27% sequentially, driven by strong AMVUTTRA launch.

TTR Franchise Growth: TTR franchise revenues reached $724 million, a 135% increase year-over-year, with U.S. TTR sales of $543 million, up 194% YoY.

Guidance Raised: 2025 net product revenue guidance increased to $2.95–3.05 billion (from $2.65–2.8B), a 10% raise at midpoint, and TTR franchise guidance raised 12%.

Strong AMVUTTRA Uptake: AMVUTTRA ATTR-CM patient demand and revenues approximately doubled quarter-over-quarter in the U.S., with broad first- and second-line adoption.

Profitability Momentum: Operating income surged, and the company reiterated progress toward sustained profitability.

Pipeline Advancements: New late-stage and early-stage clinical trials initiated, notably in hypertension, bleeding disorders, and Alzheimer’s disease.

Global Expansion: Early traction in Japan and Germany; broader international launches expected mainly in 2026.

Payer & Pricing Stability: No significant payer pushback reported; U.S. net price expected to decline mid-single digits YoY due to gross-to-net adjustments.

Key Financials
Total Net Product Revenue
$851 million
TTR Franchise Revenue
$724 million
U.S. TTR Franchise Revenue
$543 million
Rare Disease Portfolio Sales
$127 million
Collaboration Revenue
$352 million
Royalty Revenue
$46 million
Gross Margin
77%
R&D Expenses
$310 million
SG&A Expenses
$263 million
Operating Income
$476 million
Cash, Cash Equivalents and Marketable Securities
$2.7 billion
Non-GAAP Operating Expenses Guidance
$2.15–2.2 billion
Earnings Call Recording
Other Earnings Calls

Management

Dr. Akshay K. Vaishnaw M.D., Ph.D.
Chief Innovation Officer & Member of the Scientific Advisory Board
No Bio Available
Dr. Pushkal P. Garg M.D.
Chief Medical Officer
No Bio Available
Mr. Tolga Tanguler M.B.A.
Executive VP & Chief Commercial Officer
No Bio Available
Mr. Timothy J. Maines
Chief Technical Operations & Quality Officer
No Bio Available
Dr. Kevin Joseph Fitzgerald Ph.D.
Senior VP, Head of Research & Chief Scientific Officer
No Bio Available
Mr. Piyush Sharma J.D.
Chief Ethics & Compliance Officer
No Bio Available
Mr. Robert W. Hesslein Esq., J.D.
Chief Legal Officer & Corporate Secretary
No Bio Available
Mr. Evan Lippman M.B.A.
Chief Corporate Development & Strategy Officer
No Bio Available
Ms. Kelley Boucher
Chief Human Resource Officer
No Bio Available
Dr. Muthiah Manoharan Ph.D.
Senior VP of Innovation Chemistry & Distinguished Scientist and Member of Scientific Advisory Board
No Bio Available

Contacts

Address
MASSACHUSETTS
Cambridge
675 W Kendall St
Contacts
+16175518200.0
www.alnylam.com