CytomX Therapeutics Inc
NASDAQ:CTMX
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CytomX Therapeutics Inc
CytomX Therapeutics, Inc. engages in the development of antibody therapeutics for the treatment of cancer based on its Probody therapeutic technology platform. The company is headquartered in South San Francisco, California and currently employs 174 full-time employees. The company went IPO on 2015-10-08. The firm is developing a class of investigational conditionally activated therapeutics, based on its Probody technology platform, for the treatment of cancer. Its Probody technology platform is designed to enable conditional activation of antibody-based drugs in the tumor microenvironment while minimizing drug activity in healthy tissues and in circulation. The company has utilized its multi-modality Probody platform to build a pipeline of therapeutics that encompasses six product candidates, four of which are in multiple Phase II clinical studies in nine cancer indications. The company includes the conditionally activated antibody-drug conjugates (ADCs) praluzatamab ravtansine (CX-2009, targeting CD166) and CX-2029 (targeting CD71), and the Probody immune CPIs pacmilimab (CX-072, targeting PD-L1) and BMS-986249 (targeting CTLA-4).
CytomX Therapeutics, Inc. engages in the development of antibody therapeutics for the treatment of cancer based on its Probody therapeutic technology platform. The company is headquartered in South San Francisco, California and currently employs 174 full-time employees. The company went IPO on 2015-10-08. The firm is developing a class of investigational conditionally activated therapeutics, based on its Probody technology platform, for the treatment of cancer. Its Probody technology platform is designed to enable conditional activation of antibody-based drugs in the tumor microenvironment while minimizing drug activity in healthy tissues and in circulation. The company has utilized its multi-modality Probody platform to build a pipeline of therapeutics that encompasses six product candidates, four of which are in multiple Phase II clinical studies in nine cancer indications. The company includes the conditionally activated antibody-drug conjugates (ADCs) praluzatamab ravtansine (CX-2009, targeting CD166) and CX-2029 (targeting CD71), and the Probody immune CPIs pacmilimab (CX-072, targeting PD-L1) and BMS-986249 (targeting CTLA-4).
Clinical Progress: CytomX advanced its CX-2051 program in colorectal cancer with strong interim Phase I results and expanded patient enrollment, expecting around 100 patients by the next data update in Q1 2026.
CX-2051 Efficacy: CX-2051 showed a 28% confirmed response rate and preliminary median progression-free survival of 5.8 months, both substantially better than current late-line standards.
Pipeline Expansion: The company announced continued progress with CX-801 in melanoma, new preclinical programs, and is evaluating additional tumor types for CX-2051.
Financial Position: CytomX ended Q3 2025 with $143.6 million in cash and expects current funds to last at least through Q2 2027.
Cautious Spending: Operating and R&D expenses declined year-over-year, reflecting a disciplined approach to capital allocation.
Combo Trials Ahead: A Phase Ib study combining CX-2051 with bevacizumab is expected to start in Q1 2026, aiming to move into earlier treatment lines.
