Cyclerion Therapeutics Inc
NASDAQ:CYCN
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Cyclerion Therapeutics Inc
Cyclerion Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of treatments for serious and orphan diseases, through the use of soluble guanylate cyclase (sGC) pharmacology. The company is headquartered in Boston, Massachusetts and currently employs 32 full-time employees. The company went IPO on 2019-03-18. The firm's lead asset, CY6463, is a central nervous system (CNS)-penetrant, soluble guanylate cyclase (sGC) stimulator that is in clinical development for Alzheimer's disease with vascular pathology (ADv), cognitive impairment associated with schizophrenia (CIAS), and mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). CY6463 is an orally administered CNS-penetrant sGC stimulator that is being developed as a symptomatic and disease-modifying therapy for serious CNS diseases. Its CNS asset, CY3018, is a differentiated CNS-penetrant sGC stimulator with CSF-to-plasma exposure relative to CY6463. CY3018 is focused on sGC stimulation for the treatment of disorders of the CNS. Its non-CNS assets include Praliciguat and Olinciguat. Praliciguat is an orally administered, once-daily systemic sGC stimulator. Olinciguat is an orally administered, once-daily, vascular sGC stimulator.
Cyclerion Therapeutics, Inc. is a clinical-stage biopharmaceutical company, which engages in the discovery, development, and commercialization of treatments for serious and orphan diseases, through the use of soluble guanylate cyclase (sGC) pharmacology. The company is headquartered in Boston, Massachusetts and currently employs 32 full-time employees. The company went IPO on 2019-03-18. The firm's lead asset, CY6463, is a central nervous system (CNS)-penetrant, soluble guanylate cyclase (sGC) stimulator that is in clinical development for Alzheimer's disease with vascular pathology (ADv), cognitive impairment associated with schizophrenia (CIAS), and mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). CY6463 is an orally administered CNS-penetrant sGC stimulator that is being developed as a symptomatic and disease-modifying therapy for serious CNS diseases. Its CNS asset, CY3018, is a differentiated CNS-penetrant sGC stimulator with CSF-to-plasma exposure relative to CY6463. CY3018 is focused on sGC stimulation for the treatment of disorders of the CNS. Its non-CNS assets include Praliciguat and Olinciguat. Praliciguat is an orally administered, once-daily systemic sGC stimulator. Olinciguat is an orally administered, once-daily, vascular sGC stimulator.
Corporate Launch: Cyclerion completed its spinout and began trading on NASDAQ as an independent public company, supported by a $165 million private placement.
Pipeline Progress: The company is advancing five programs, with four ongoing clinical trials, including three Phase II studies that have all completed enrollment.
Data Timing: Top-line results from the praliciguat Phase II studies in diabetic nephropathy and heart failure with preserved ejection fraction (HFpEF) are expected in Q4 2019.
Sickle Cell Study: The STRONG SCD trial for olinciguat in sickle cell disease has expanded to include a higher dose and now includes ex-U.S. sites, with top-line data expected mid-2020.
Strong Cash Position: Management expects current cash to fund multiple upcoming clinical milestones.
