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Halozyme Therapeutics Inc
NASDAQ:HALO

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Halozyme Therapeutics Inc
NASDAQ:HALO
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Price: 68.01 USD 1.54%
Market Cap: $8B

Halozyme Therapeutics Inc
Investor Relations

Halozyme Therapeutics Inc., a California-based biopharmaceutical company, weaves innovation with practicality in the realm of drug delivery. The narrative of Halozyme is centered around its proprietary enzyme technology, known as ENHANZE®. This platform is a transformative approach that leverages a recombinant human hyaluronidase enzyme, named rHuPH20. This enzyme temporarily degrades hyaluronan, a key component in the extracellular matrix, thereby allowing for quicker dispersal and absorption of subcutaneous drugs. By facilitating the transition of therapies from intravenous to subcutaneous administration, Halozyme not only enhances the patient experience with less clinic time and reduced infusion-related costs but also provides pharmaceutical partners with the opportunity to extend the lifecycle of their drugs.

The company’s revenue generation resembles a carefully orchestrated symphony, harmonizing collaboration and licensing agreements with prominent pharmaceutical giants such as Roche and Bristol-Myers Squibb. Halozyme earns through a blend of upfront licensing fees, milestone payments, and royalties on product sales that incorporate the ENHANZE® technology. These alliances empower its partners to broaden the utility of their existing drug formulations, while Halozyme benefits from a steady cash inflow that supports its ongoing research and development activities. In essence, Halozyme’s business model thrives on creating value by enhancing drug delivery mechanisms, ensuring that its innovations are profitable not only for the partners it collaborates with but also for patients worldwide who benefit from its advancements.

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Last Earnings Call
Fiscal Period
Q4 2025
Call Date
Feb 17, 2026
AI Summary
Q4 2025

Record Revenue: Halozyme reported total revenue of $1.4 billion for 2025, up 38% year-over-year, driven by strong ENHANZE-enabled royalty streams.

Royalty Growth: Royalty revenue jumped 52% to $867.8 million, fueled by products like DARZALEX, PHESGO, and VYVGART Hytrulo.

Blockbuster Products: DARZALEX SC, PHESGO, and VYVGART Hytrulo all delivered significant growth, with DARZALEX sales reaching $14.4 billion and PHESGO up 48% year-over-year.

Strategic Acquisitions: Acquisitions of Elektrofi's Hypercon and Surf Bio's technology expanded Halozyme's drug delivery platform and IP into the mid-2040s.

2026 Guidance Reiterated: Management reiterated 2026 guidance, projecting $1.71–$1.81 billion total revenue (22–30% growth), $1.13–$1.17 billion royalty revenue (30–35% growth), and $7.75–$8.25 in non-GAAP diluted EPS.

Pipeline Expansion: Six new ENHANZE programs and two Hypercon programs are set to enter Phase I in 2026, with more licensing deals expected.

Cash Flow & Balance Sheet: Strong cash generation, disciplined financial execution, and a healthier capital structure set up for future growth and further M&A.

Key Financials
Total Revenue
$1.4 billion
Royalty Revenue
$867.8 million
DARZALEX Total Sales
$14.4 billion
DARZALEX Royalty Revenue
$483 million
PHESGO Sales
$3 billion (approximate, converted from CHF 2.4 billion)
PHESGO Royalty Revenue
$105.6 million
VYVGART and VYVGART Hytrulo Sales
$4.15 billion
VYVGART Hytrulo Royalty Revenue
$157.2 million
OCREVUS Franchise Sales Expectation
$11.5 billion (approximate, converted from CHF 9 billion)
OPDIVO Qvantig Sales (Q4)
$133 million
Net Income
$316.9 million
Adjusted EBITDA
$657.6 million
Diluted EPS
$2.56
Non-GAAP Diluted EPS
$4.15
Cost of Sales
$228.8 million
R&D Expense
$81.5 million
SG&A Expense
$207.1 million
Amortization of Intangibles
$76.7 million
Fourth Quarter Total Revenue
$451.8 million
Fourth Quarter Royalty Revenue
$258 million
Net Debt to EBITDA
2.1x (year-end 2025)
Earnings Call Recording
Other Earnings Calls

Management

Dr. Helen I. Torley M.B. Ch. B., M.R.C.P.
President, CEO & Director
No Bio Available
Dr. Michael J. LaBarre Ph.D.
Senior VP & CTO
No Bio Available
Ms. Cortney Caudill M.B.A.
Chief Operations Officer
No Bio Available
Ms. Tram Bui
Head of Investor Relations & Corporate Communications
No Bio Available
Ms. Amy Marinne Fox
Chief Human Resources Officer
No Bio Available
Mr. Gary Grote
Chief Commercial Officer
No Bio Available
Dr. Christopher Wahl M.B.A., M.D.
Chief Business Officer
No Bio Available
Dr. Charles P. Theuer M.D., Ph.D.
Chief Medical Officer
No Bio Available

Contacts

Address
CALIFORNIA
San Diego
11388 Sorrento Valley Rd
Contacts
+18587948889.0
www.halozyme.com
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