Seres Therapeutics Inc
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Seres Therapeutics Inc
Seres Therapeutics, Inc. engages in the development of biological drugs through microbiome therapeutics platform. The company is headquartered in Cambridge, Massachusetts and currently employs 333 full-time employees. The company went IPO on 2015-06-26. The firm is engaged in developing a class of biological drugs, which are designed to treat disease by modulating the microbiome to restore health by repairing the function of a disrupted microbiome to a non-disease state. The firm's lead product candidate, SER-109, is designed to reduce further recurrences of Clostridioides difficle infection (CDI). The company is also developing therapeutics, such as SER-155, to specifically target infections and antimicrobial resistance. SER-155, a microbiome therapeutic candidate consisting of a consortium of cultivated bacteria, is designed to reduce incidences of gastrointestinal infections, bloodstream infections and graft versus host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). In addition, using its microbiome therapeutics platform, the Company is developing SER-287 and SER-301 to treat ulcerative colitis (UC).
Seres Therapeutics, Inc. engages in the development of biological drugs through microbiome therapeutics platform. The company is headquartered in Cambridge, Massachusetts and currently employs 333 full-time employees. The company went IPO on 2015-06-26. The firm is engaged in developing a class of biological drugs, which are designed to treat disease by modulating the microbiome to restore health by repairing the function of a disrupted microbiome to a non-disease state. The firm's lead product candidate, SER-109, is designed to reduce further recurrences of Clostridioides difficle infection (CDI). The company is also developing therapeutics, such as SER-155, to specifically target infections and antimicrobial resistance. SER-155, a microbiome therapeutic candidate consisting of a consortium of cultivated bacteria, is designed to reduce incidences of gastrointestinal infections, bloodstream infections and graft versus host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). In addition, using its microbiome therapeutics platform, the Company is developing SER-287 and SER-301 to treat ulcerative colitis (UC).
SER-155 Progress: Key priority remains advancing SER-155 into Phase II for preventing bloodstream infections in allo-HSCT patients, with positive interim data expected within 12 months of study start, pending funding.
FDA Alignment: Seres received constructive FDA feedback and has alignment on critical Phase II study parameters, clearing protocol hurdles to begin the trial once funding is secured.
Financial Update: Reported $8.2 million net income from continuing operations in Q3, a turnaround from a $51 million loss last year, primarily due to a $25 million payment from the VOWST sale.
Cost Reductions: Implemented targeted cost cuts, including a 25% workforce reduction, to extend cash runway through Q2 2026.
New Funding: Received up to $3.6 million in non-dilutive CARB-X funding to develop an oral liquid formulation of SER-155 for broader patient access.
Clinical Expansion: Ongoing investigator-sponsored trial at MSK is evaluating SER-155 in immune-related enterocolitis, with initial safety and symptom data anticipated in early 2026.
Partnership Focus: Securing capital or partnerships to advance SER-155 is top priority, though no specifics were disclosed about ongoing discussions.