Rhythm Pharmaceuticals Inc
NASDAQ:RYTM

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Rhythm Pharmaceuticals Inc Logo
Rhythm Pharmaceuticals Inc
NASDAQ:RYTM
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Price: 112.52 USD -0.92% Market Closed
Market Cap: 7.5B USD

Rhythm Pharmaceuticals Inc
Investor Relations

Rhythm Pharmaceuticals Inc. emerged with a resolute focus, aiming to transform the landscape for individuals grappling with rare genetic disorders of obesity. Founded on the premise that certain predispositions to obesity are deeply rooted in genetics, Rhythm embarked on a journey to develop treatments that target the melanocortin-4 receptor (MC4R) pathway. This pathway plays a critical role in regulating hunger, energy expenditure, and overall body weight. Their flagship product, Imcivree (setmelanotide), gained approval and marked a significant stride forward for the company. It is specifically designed to address the underlying genetic causes of obesity, offering hope to patients who previously had limited therapeutic options.

The business model of Rhythm Pharmaceuticals is patient-centric, grounded in innovation and strategic collaborations. They generate revenue through the commercialization of Imcivree, facilitated by partnerships with healthcare providers and institutions that benefit from the specialized treatment they offer. Additionally, Rhythm actively invests in research and development, continually seeking to expand the applicability of their products to other genetic obesity-related conditions. By maintaining a robust pipeline and leveraging scientific advancements, the company positions itself as a pioneer in addressing an underserved niche, sustainably growing through targeted drug development and market expansion initiatives.

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Last Earnings Call
Fiscal Period
Q3 2025
Call Date
Nov 4, 2025
AI Summary
Q3 2025

Revenue Growth: Rhythm reported Q3 revenue of $51.3 million, a 6% sequential increase and 54% higher than Q3 2024, driven by steady growth in IMCIVREE sales.

IMCIVREE Expansion: The company is preparing to launch IMCIVREE for acquired hypothalamic obesity (HO), with an FDA PDUFA date set for December 20, 2025, calling it a transformative opportunity.

Global Progress: IMCIVREE is now available across more than 25 countries, with expanding reimbursement, including a new agreement in France and continued early access programs in France and Italy for HO.

Financial Strength: Rhythm raised $189 million in equity in July and ended Q3 with $416 million in cash, providing at least 24 months of operational runway.

Clinical Pipeline: Robust clinical activity continues, with a Phase II Prader-Willi syndrome (PWS) readout expected by year-end, ongoing Phase III development, and future launches planned in Europe and Japan.

Guidance Update: Full-year 2025 operating expense guidance was tightened, with R&D expected at $150–165 million and SG&A at $145–150 million.

Patient Identification: The company has identified more than 2,000 potential HO patients in the US through physician profiling and claims data analysis, aiming to accelerate diagnosis and treatment.

Key Financials
Revenue
$51.3 million
Cash and Equivalents
$416 million
US Net Revenue
$38.2 million
International Net Revenue
$13.1 million
Gross to Net for US Sales
84%
Cost of Goods Sold
10.7% of product revenue
R&D Expenses
$46 million
SG&A Expenses
$52.4 million
Operating Expenses
$98.5 million (Q3 2025)
Earnings Per Share (EPS)
-$0.82
Weighted Average Shares Outstanding
66.3 million
Cash Used in Operations
$27 million
Earnings Call Recording
Other Earnings Calls

Management

Dr. David P. Meeker M.D.
Chairman, President & CEO
No Bio Available
Mr. Hunter C. Smith M.B.A.
CFO & Treasurer
No Bio Available
Mr. Joseph Shulman
Chief Technical Officer
No Bio Available
Mr. Yann Mazabraud
Executive VP & Head of International
No Bio Available
Mr. Christopher German
Corporate Controller, Principal Accounting Officer & Executive Director
No Bio Available
Dr. Alastair Garfield Ph.D.
Chief Scientific Officer
No Bio Available
Mr. David Connolly
Head of Investor Relations & Corporate Communications
No Bio Available
Mr. Jim Flaherty
Senior VP & General Counsel
No Bio Available
Ms. Sarah Ryan
Vice President of Sales & Marketing
No Bio Available
Ms. Pamela J. Cramer
Chief Human Resources Officer
No Bio Available

Contacts

Address
MASSACHUSETTS
Boston
222 Berkeley St Fl 12
Contacts
+18572644280.0
www.rhythmtx.com