Simulations Plus Inc
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Simulations Plus Inc
Simulations Plus, Inc. provides modeling and simulation software and consulting services supporting drug discovery, development research and regulatory submissions. The company is headquartered in Lancaster, California and currently employs 135 full-time employees. The company provides prediction of properties of molecules utilizing artificial-intelligence- and machine-learning-based technology. The company also provides consulting services ranging from early drug discovery through preclinical and clinical trial development to regulatory submissions in support of product approval. The company offers 11 software products for pharmaceutical research and development, which includes GastroPlus, DDDPlus, MembranePlus, DILIsym, NAFLDsym, ADMET Predictor, MedChem Designer, MedChem Studio, PKPlus, KIWI and Monolix Suite of products through Lixoft. Its software and consulting services are provided to pharmaceutical, biotechnology, agrochemical, cosmetics, and food industry companies and to academic and regulatory agencies worldwide for use in the conduct of industry-based research. Cognigen Corporation, DILIsym Services, Inc. and Lixoft are its subsidiaries.
Simulations Plus, Inc. provides modeling and simulation software and consulting services supporting drug discovery, development research and regulatory submissions. The company is headquartered in Lancaster, California and currently employs 135 full-time employees. The company provides prediction of properties of molecules utilizing artificial-intelligence- and machine-learning-based technology. The company also provides consulting services ranging from early drug discovery through preclinical and clinical trial development to regulatory submissions in support of product approval. The company offers 11 software products for pharmaceutical research and development, which includes GastroPlus, DDDPlus, MembranePlus, DILIsym, NAFLDsym, ADMET Predictor, MedChem Designer, MedChem Studio, PKPlus, KIWI and Monolix Suite of products through Lixoft. Its software and consulting services are provided to pharmaceutical, biotechnology, agrochemical, cosmetics, and food industry companies and to academic and regulatory agencies worldwide for use in the conduct of industry-based research. Cognigen Corporation, DILIsym Services, Inc. and Lixoft are its subsidiaries.
Full-Year Delivery: Simulations Plus met its fiscal 2025 guidance, with revenue up 13% and adjusted EBITDA and EPS each growing 8%, despite a volatile market.
Q4 Weakness: Fourth-quarter revenue declined 6% year-over-year to $17.5 million, with software down 9% and services down 3%, reflecting ongoing market pressures and client consolidations.
Impairment Impact: Reported a net loss of $64.7 million and diluted loss per share of $3.22 for the year, largely due to a $77.2 million non-cash impairment charge.
2026 Guidance Maintained: Management reaffirmed fiscal 2026 guidance: revenue of $79–82 million (0–4% growth), adjusted EBITDA margin of 26–30%, and adjusted EPS of $1.03–$1.10.
Q1 2026 Softness: First-quarter 2026 revenue is expected to be 3–5% lower than the prior year period, mainly due to tough comps and seasonality.
Operating Model Shift: Completed a transition to a unified, client-focused structure, aiming for faster innovation and more integrated product offerings.
AI and Cloud Focus: Rolled out AI features in GastroPlus and plans further portfolio integration, with early positive client feedback.
Market Stabilization: Management sees early signs of stabilization in pharma and biotech, but remains cautious given ongoing uncertainties.
Renewal Rates Below Historical Levels: Software renewal rates dipped to 83% in Q4 and 88% for the year, impacted by client consolidation and tighter module scrutiny.
