Silence Therapeutics PLC
OTC:SLNCF
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Silence Therapeutics PLC
Silence Therapeutics Plc engages in the discovery, delivery and development of ribonucleic acid (RNA) therapeutics. The firm is focused on discovering and developing molecules combining short interfering ribonucleic acid (siRNA), to inhibit the expression of target genes in the pathology of diseases with unmet medical need. Its siRNA molecules are designed to harness the body’s natural mechanism of RNA interference (RNAi), by specifically binding to and degrading messenger RNA, or mRNA, molecules that encode specific targeted disease-associated proteins in a cell. The Company’s mRNAi GOLD (GalNAc Oligonucleotide Discovery) platform is a platform of precision-engineered medicines designed to target for specific disease-associated genes in the liver. The Company’s clinical development programs include SLN360, for the prevalent unmet need in reducing cardiovascular risk in people born with Lipoprotein(a), or Lp(a), levels and SLN124, for rare iron loading anemia conditions, including thalassemia and myelodysplastic syndrome (MDS).
Silence Therapeutics Plc engages in the discovery, delivery and development of ribonucleic acid (RNA) therapeutics. The firm is focused on discovering and developing molecules combining short interfering ribonucleic acid (siRNA), to inhibit the expression of target genes in the pathology of diseases with unmet medical need. Its siRNA molecules are designed to harness the body’s natural mechanism of RNA interference (RNAi), by specifically binding to and degrading messenger RNA, or mRNA, molecules that encode specific targeted disease-associated proteins in a cell. The Company’s mRNAi GOLD (GalNAc Oligonucleotide Discovery) platform is a platform of precision-engineered medicines designed to target for specific disease-associated genes in the liver. The Company’s clinical development programs include SLN360, for the prevalent unmet need in reducing cardiovascular risk in people born with Lipoprotein(a), or Lp(a), levels and SLN124, for rare iron loading anemia conditions, including thalassemia and myelodysplastic syndrome (MDS).
Revenue Growth: Revenue for 2024 rose to $43.3 million from $31.6 million in 2023, mainly due to collaboration agreements.
Zerlasiran Phase III: Phase III outcomes study for zerlasiran will only start once a partner is secured, extending cash runway into 2027.
Divesiran Progress: Divesiran's Phase I data in polycythemia vera were positive, eliminating phlebotomy need in well-controlled patients; Phase II on track for full enrollment by year-end.
Pipeline Prioritization: Silence is prioritizing programs for rare diseases, aiming to invest flexibly while continuing zerlasiran partnership talks.
Cash Position: Ended 2024 with $147.3 million in cash and investments; runway now extends into 2027 due to delayed zerlasiran Phase III.
Hansoh Collaboration Ended: Hansoh Pharma opted out of further development; Silence regains control of three preclinical liver targets.
SLN548 Advancement: Plans to begin Phase I trial of SLN548 targeting complement factor B in 2H 2025.
