Akebia Therapeutics Inc
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Akebia Therapeutics Inc
Akebia Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of therapeutics for patients with kidney diseases. The company is headquartered in Cambridge, Massachusetts and currently employs 426 full-time employees. The company went IPO on 2014-03-20. The firm is focused on producing medicines for people living with kidney disease. Its lead product candidate, vadadustat, is an oral therapy in development for the treatment of anemia due to chronic kidney disease (CKD). Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), designed to mimic the physiologic effect of altitude on oxygen availability. In addition, it has a commercial product, Auryxia (ferric citrate), which is marketed for two indications in the United States: the control of serum phosphorus levels in adult patients with dialysis-dependent (DD)-CKD or the hyperphosphatemia indication, and the treatment of iron deficiency anemia (IDA), in adult patients with non-dialysis dependent (NDD)-CKD or the IDA indication. Its ferric citrate is also approved and marketed in Japan as an oral treatment for the improvement of hyperphosphatemia in patients with CKD.
Akebia Therapeutics, Inc. is a biopharmaceutical company, which engages in the development and commercialization of therapeutics for patients with kidney diseases. The company is headquartered in Cambridge, Massachusetts and currently employs 426 full-time employees. The company went IPO on 2014-03-20. The firm is focused on producing medicines for people living with kidney disease. Its lead product candidate, vadadustat, is an oral therapy in development for the treatment of anemia due to chronic kidney disease (CKD). Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), designed to mimic the physiologic effect of altitude on oxygen availability. In addition, it has a commercial product, Auryxia (ferric citrate), which is marketed for two indications in the United States: the control of serum phosphorus levels in adult patients with dialysis-dependent (DD)-CKD or the hyperphosphatemia indication, and the treatment of iron deficiency anemia (IDA), in adult patients with non-dialysis dependent (NDD)-CKD or the IDA indication. Its ferric citrate is also approved and marketed in Japan as an oral treatment for the improvement of hyperphosphatemia in patients with CKD.
Vafseo Launch: Vafseo revenue reached $13.3 million in Q2, up 55% from Q1, with rapid progress in gaining access to more dialysis patients.
Patient Access Expansion: Prescribing access is expected to rise from 40,000 to over 75,000 dialysis patients in Q3, and to more than 275,000 by Q4 with the DaVita rollout.
Record Revenues: Akebia achieved $62.5 million in total revenue and $60.5 million in net product revenue, both up sharply year-over-year and the highest in company history.
Auryxia Resilience: Auryxia sales were strong at $47.2 million despite loss of IP exclusivity, though management remains cautious about future generic competition.
Profitability Reached: The company posted $247,000 in net income for Q2, swinging from a net loss last year.
Solid Cash Position: Ended Q2 with $137.3 million in cash and equivalents, expected to fund operations to profitability.
Clinical Pipeline Progress: Key Vafseo trials (VOICE, VOCAL) are advancing, and Akebia is working to start the VALOR Phase III trial for label expansion in nondialysis CKD by year-end.
