Cytokinetics Inc
NASDAQ:CYTK

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Cytokinetics Inc
NASDAQ:CYTK
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Price: 63.35 USD 4.25% Market Closed
Market Cap: 7.7B USD

Cytokinetics Inc
Investor Relations

Cytokinetics Inc., rooted firmly in the heart of California's biotechnology hub, has carved a niche in the complex arena of muscle biology. Founded in 1998, the company has focused its considerable expertise on the intricacies of muscle function, especially targeting conditions characterized by impaired muscle performance such as heart failure, ALS, and even SMA. Rather than pursuing the well-trodden paths of traditional pharmaceuticals, Cytokinetics delves into the uncharted realms of muscle contractility, leveraging its proprietary muscle biology expertise to develop small molecule therapeutics. Their pipeline is rich with candidates that promise to enhance muscle function, representing a blend of hope and scientific innovation for conditions that, until now, have seen few breakthroughs.

As a business, Cytokinetics operates at the confluence of innovative science and strategic partnerships. Financially, the company nurtures its pipeline through the judicious blend of equity financing, collaboration revenues, and milestone payments. Strategic alliances with larger pharmaceutical companies, such as collaborations previously established with Amgen and Astellas, play a pivotal role; these partnerships not only provide capital but also benefit from shared resources and expanded market reach. With therapies still largely in development, the company's revenue streams are intertwined with the success of clinical trials and approvals, rendering each scientific step a potential catalyst for investor interest and market value growth.

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Last Earnings Call
Fiscal Period
Q3 2025
Call Date
Nov 5, 2025
AI Summary
Q3 2025

FDA Approval Near: Cytokinetics is preparing for potential first FDA approval of aficamten for oHCM by year-end, with launch plans set to begin immediately upon approval.

Strong Clinical Data: MAPLE-HCM trial results showed aficamten’s superiority to metoprolol in oHCM, supporting broad interest among cardiologists and a potentially differentiated label.

Commercial Launch Ready: The company reported advanced US commercial readiness, with a fully trained sales force and support infrastructure in place, and similar preparations underway in Europe.

Financial Flexibility: Cytokinetics ended Q3 with $1.25 billion in cash and investments after bolstering its capital through a convertible note transaction and a loan from Royalty Pharma.

Guidance Narrowed: Operating expense guidance for 2025 was narrowed to $680–700 million, with no indications of immediate need for further capital.

Pipeline Progress: Enrollment completed for the ACACIA-HCM Phase 3 trial in nHCM; top-line results expected in Q2 2026. Ongoing progress reported for other key pipeline programs.

Market Expansion Strategy: Management expects aficamten pricing in line with mavacamten and is targeting rapid adoption among the top 650 prescribers, with early patient support programs to facilitate uptake.

Key Financials
Cash and Investments
$1.25 billion
R&D Expenses
$99.2 million
G&A Expenses
$69.5 million
Net Loss
$306.2 million
EPS
-$2.55
Operating Expense Guidance (2025)
$680–700 million
Stock-Based Compensation (2025)
$110–120 million
Cash Excluding Convertible Note Proceeds (Q3 2025)
$1.14 billion
Earnings Call Recording
Other Earnings Calls

Management

Mr. Robert I. Blum
CEO, President & Director
No Bio Available
Mr. Robert C. Wong
VP & Chief Accounting Officer
No Bio Available
Dr. Fady Ibraham Malik FACC, M.D., Ph.D.
Executive Vice President of Research & Development
No Bio Available
Mr. Andrew M. Callos
Executive VP & Chief Commercial Officer
No Bio Available
Dr. James A. Spudich Ph.D.
Co-Founder & Member of Scientific Advisory Board
No Bio Available
Mr. Sung H. Lee
Executive VP & CFO
No Bio Available
Mr. Jeff Lotz
Vice President of Sales & Operations
No Bio Available
Mr. Matt Yang
Vice President of Corporate Finance and Financial Planning & Analysis
No Bio Available
Mr. Steven M. Cook J.D.
Senior Vice President of Global Supply Chain Operations & Technical Operations
No Bio Available
Ms. Kari K. Loeser J.D.
VP & Chief Compliance Officer
No Bio Available

Contacts

Address
CALIFORNIA
South San Francisco
350 Oyster Point Boulevard, .
Contacts
+16506243000.0
cytokinetics.com