FibroGen Inc
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FibroGen Inc
FibroGen, Inc. is a biopharmaceutical company, which engages in the discovery, development, and commercialization of novel therapeutics. The company is headquartered in San Francisco, California and currently employs 566 full-time employees. The company went IPO on 2014-11-14. The firm is engaged in discovering, developing and commercializing a pipeline of therapeutics. The company applies its capabilities in hypoxia-inducible factor (HIF) biology, 2-oxoglutarate enzymology, and connective tissue growth factor (CTGF) biology to advance medicines for the treatment of anemia, fibrotic disease, and cancer. The Company’s product Roxadustat is an oral small molecule inhibitor of HIF-prolyl hydroxylase activity for the treatment of anemia caused by chronic kidney disease (CKD). The company is also developing Roxadustat for anemia associated with myelodysplastic syndromes. The company also develops Roxadustat for the treatment of chemotherapy-induced anemia (CIA). Pamrevlumab, an anti-CTGF human monoclonal antibody for the treatment of idiopathic pulmonary fibrosis (IPF), locally advanced unresectable pancreatic cancer, and Duchenne muscular dystrophy. The firm is also enrolling patients in its two Phase III trials of pamrevlumab patients.
FibroGen, Inc. is a biopharmaceutical company, which engages in the discovery, development, and commercialization of novel therapeutics. The company is headquartered in San Francisco, California and currently employs 566 full-time employees. The company went IPO on 2014-11-14. The firm is engaged in discovering, developing and commercializing a pipeline of therapeutics. The company applies its capabilities in hypoxia-inducible factor (HIF) biology, 2-oxoglutarate enzymology, and connective tissue growth factor (CTGF) biology to advance medicines for the treatment of anemia, fibrotic disease, and cancer. The Company’s product Roxadustat is an oral small molecule inhibitor of HIF-prolyl hydroxylase activity for the treatment of anemia caused by chronic kidney disease (CKD). The company is also developing Roxadustat for anemia associated with myelodysplastic syndromes. The company also develops Roxadustat for the treatment of chemotherapy-induced anemia (CIA). Pamrevlumab, an anti-CTGF human monoclonal antibody for the treatment of idiopathic pulmonary fibrosis (IPF), locally advanced unresectable pancreatic cancer, and Duchenne muscular dystrophy. The firm is also enrolling patients in its two Phase III trials of pamrevlumab patients.
China Transaction: FibroGen completed the sale of its China operations to AstraZeneca for about $220 million, a move described as transformative that extended its cash runway into 2028.
Pipeline Progress: The company initiated a Phase II trial for lead asset FG-3246 (a CD46-targeting ADC for prostate cancer) and expects top-line results from a key combination trial in Q1 2026.
Roxadustat Update: Following a successful FDA Type C meeting, FibroGen will submit a pivotal Phase III protocol for roxadustat in lower-risk MDS by year-end, targeting a significant unmet need.
Cost Reductions: Operating costs for Q3 dropped dramatically (down 86% YoY), and full-year costs are forecasted to be 70% lower than in 2024.
Financials: Q3 revenue rose to $1.1 million, and the company ended September with $121.1 million in cash and equivalents.
Strategic Flexibility: Management is evaluating whether to partner or self-fund the Phase III roxadustat trial, with clarity expected by Q2 2026.
Royalty Liabilities: A $63 million liability relates to royalties payable to NovaQuest from roxadustat sales in partnered regions, not from ADC milestones.
