Immuneering Corp
NASDAQ:IMRX
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Immuneering Corp
Immuneering Corp. engages in the development of new medicines which are unlikely to be found by traditional drug discovery methods. The company is headquartered in Cambridge, Massachusetts and currently employs 64 full-time employees. The company went IPO on 2021-07-30. The firm is focused on improving patient outcomes by advancing a pipeline of oncology and neuroscience product candidates developed using its translational bioinformatics platform. Its development programs in oncology are focused on providing treatments for patients with solid tumors caused by mutations of the MAPK and mTOR pathways. Its lead product candidate, IMM-1-104, is designed to be a selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. The firm's oncology programs target mutations of the RAS/RAF/MEK/ERK, (MAPK) and the PI3K/AKT/mTOR (mTOR), pathways. Its oncology programs include Dual-MEK: IMM-1-104, MEK-io, Trifecta-MEK, KRAS4B, RAS Induction, Covalent-MEK, and PI3K-alpha. The firm's neuroscience pipeline on Alzheimer's Disease (AD). Its neuroscience programs include IMM-ALL-01 and IMM-ALL-03.
Immuneering Corp. engages in the development of new medicines which are unlikely to be found by traditional drug discovery methods. The company is headquartered in Cambridge, Massachusetts and currently employs 64 full-time employees. The company went IPO on 2021-07-30. The firm is focused on improving patient outcomes by advancing a pipeline of oncology and neuroscience product candidates developed using its translational bioinformatics platform. Its development programs in oncology are focused on providing treatments for patients with solid tumors caused by mutations of the MAPK and mTOR pathways. Its lead product candidate, IMM-1-104, is designed to be a selective dual-MEK inhibitor that further disrupts KSR for the treatment of advanced solid tumors in patients harboring RAS mutant tumors. The firm's oncology programs target mutations of the RAS/RAF/MEK/ERK, (MAPK) and the PI3K/AKT/mTOR (mTOR), pathways. Its oncology programs include Dual-MEK: IMM-1-104, MEK-io, Trifecta-MEK, KRAS4B, RAS Induction, Covalent-MEK, and PI3K-alpha. The firm's neuroscience pipeline on Alzheimer's Disease (AD). Its neuroscience programs include IMM-ALL-01 and IMM-ALL-03.
Extraordinary Survival: Immuneering reported 86% overall survival at 9 months for first-line pancreatic cancer patients treated with atebimetinib plus gemcitabine/nab-paclitaxel, far exceeding standard care.
Case Studies: Investigators highlighted two remarkable patient responses to atebimetinib plus FOLFIRINOX, including a complete response and conversion to surgical eligibility in metastatic pancreatic cancer.
Tolerability: Both patients in case studies experienced improved quality of life and stable weight, with unexpected good tolerability noted by investigators.
Strong Financials: Cash and cash equivalents reached $227.6 million as of September 30, 2025, with a cash runway expected to fund operations into 2029.
Expanded Opportunities: Management emphasized the potential for atebimetinib in combinations beyond the current top priority, including with FOLFIRINOX and in other tumor types.
Upcoming Catalysts: Key milestones ahead include beginning pivotal trials in pancreatic and lung cancer and sharing additional data in 2026.
Patent & Partnerships: Composition of matter patent for atebimetinib granted, with patent life into 2042 or beyond, and new collaboration agreements with Eli Lilly and Regeneron.
