Iterum Therapeutics PLC
NASDAQ:ITRM
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Iterum Therapeutics PLC
Iterum Therapeutics Plc operates as a pharmaceutical company, which engages in the development and commercialization of sulopenem to be potentially the first and only oral and intravenous (IV) branded penem available. The company is headquartered in Dublin, Dublin and currently employs 13 full-time employees. The company went IPO on 2018-05-25. The firm is focused on developing significantly differentiated anti-infectives aimed at combatting the global crisis of multi-drug resistant (MDR) pathogens. The firm is developing sulopenem - the oral and intervenous (IV) penem antibiotic demonstrating a potent spectrum of activity against multi-drug resistant gram-negative. The company is a bioavailable, antibiotic covering gram-positive, gram-negative and anaerobic pathogen with in-vitro activity against multidrug-resistant pathogens, including Extended-Spectrum Beta-Lactamase (ESBL)-producing Escherichia, coli and Klebsiella and pneumonia. The firm also developed sulopenem in an oral tablet formulation, sulopenem etzadroxil-probenecid, which is known as oral sulopenem.
Iterum Therapeutics Plc operates as a pharmaceutical company, which engages in the development and commercialization of sulopenem to be potentially the first and only oral and intravenous (IV) branded penem available. The company is headquartered in Dublin, Dublin and currently employs 13 full-time employees. The company went IPO on 2018-05-25. The firm is focused on developing significantly differentiated anti-infectives aimed at combatting the global crisis of multi-drug resistant (MDR) pathogens. The firm is developing sulopenem - the oral and intervenous (IV) penem antibiotic demonstrating a potent spectrum of activity against multi-drug resistant gram-negative. The company is a bioavailable, antibiotic covering gram-positive, gram-negative and anaerobic pathogen with in-vitro activity against multidrug-resistant pathogens, including Extended-Spectrum Beta-Lactamase (ESBL)-producing Escherichia, coli and Klebsiella and pneumonia. The firm also developed sulopenem in an oral tablet formulation, sulopenem etzadroxil-probenecid, which is known as oral sulopenem.
Product Launch: ORLYNVAH was launched in the U.S. in August 2025, targeting uncomplicated urinary tract infections.
Early Commercial Metrics: Over 280 prescriptions have been filled by more than 100 unique prescribers, with nearly half prescribing to more than one patient.
Payer Coverage: ORLYNVAH currently has coverage for 16% of insured lives, with a rebate agreement signed with a top 3 Medicare Part D pharmacy benefit manager and broader formulary submissions underway.
Financial Results: Q3 2025 net product revenue was $0.4 million, while operating expenses increased to $8.1 million due to commercialization efforts.
2026 Guidance: Full-year 2026 net product revenue is expected in the range of $5 million to $15 million, with operating expenses estimated at $25 million to $30 million.
Runway & Funding: Current cash expected to fund operations into Q2 2026; additional capital will be needed to sustain commercialization beyond this period.
Field Force Optimization: The in-person field team was reduced from 20 to 10 reps with plans to supplement with virtual reps for broader and more efficient coverage.