Oric Pharmaceuticals Inc
NASDAQ:ORIC
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Oric Pharmaceuticals Inc
Oric Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company, which engages in the development of cancer treatments that address mechanisms of therapeutic resistance. The company is headquartered in South San Francisco, California and currently employs 78 full-time employees. The company went IPO on 2020-04-24. The firm is focused on developing a diverse pipeline of therapies designed to counter resistance mechanisms in cancer by leveraging its experience within three specific areas: hormone-dependent cancers, precision oncology and key tumor dependencies. Its product candidates include ORIC-101, ORIC-533, ORIC-944 and ORIC-114. The Company’s ORIC-101 is a potent and selective small-molecule antagonist of the glucocorticoid receptor (GR), which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. The Company’s second product candidate, ORIC-533, is an orally bioavailable, small-molecule inhibitor of CD73, a key node in the adenosine pathway in resistance to chemotherapy-and immunotherapy-based treatment regimens. Its ORIC-944, is being developed for prostate cancer and breast cancer.
Oric Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company, which engages in the development of cancer treatments that address mechanisms of therapeutic resistance. The company is headquartered in South San Francisco, California and currently employs 78 full-time employees. The company went IPO on 2020-04-24. The firm is focused on developing a diverse pipeline of therapies designed to counter resistance mechanisms in cancer by leveraging its experience within three specific areas: hormone-dependent cancers, precision oncology and key tumor dependencies. Its product candidates include ORIC-101, ORIC-533, ORIC-944 and ORIC-114. The Company’s ORIC-101 is a potent and selective small-molecule antagonist of the glucocorticoid receptor (GR), which has been linked to resistance to multiple classes of cancer therapeutics across a variety of solid tumors. The Company’s second product candidate, ORIC-533, is an orally bioavailable, small-molecule inhibitor of CD73, a key node in the adenosine pathway in resistance to chemotherapy-and immunotherapy-based treatment regimens. Its ORIC-944, is being developed for prostate cancer and breast cancer.
ORIC-101 Discontinued: ORIC is halting further development of its lead program, ORIC-101, after two clinical trials failed to show sufficient efficacy in overcoming resistance in solid tumors and prostate cancer.
Pipeline Focus: Despite the setback, ORIC highlights a robust pipeline, with three new clinical programs (ORIC-533, ORIC-114, ORIC-944) active and initial Phase 1 data expected in the first half of 2023.
Financial Position: Ending 2021 with $280.4 million in cash and investments, ORIC has extended its cash runway into the second half of 2024 due to reduced spending from discontinuing ORIC-101.
Trial Findings: Both ORIC-101 studies demonstrated target engagement and tolerability, but no meaningful clinical benefit across key endpoints, so the company is reallocating resources.
Strategic Discipline: Management emphasized fast, data-driven decision making and intends to pursue both novel and validated targets, maintaining a mix of potential first- and best-in-class therapies.
Analyst Q&A: Management clarified differences with competitor studies, provided specifics on patient responses, and discussed learnings around tumor heterogeneity and resistance mechanisms.
