Zymeworks Inc
NASDAQ:ZYME
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Zymeworks Inc
Zymeworks Inc. is a biopharmaceutical company. The company is headquartered in Middletown, Delaware and currently employs 286 full-time employees. The company went IPO on 2019-06-24. Its lead product candidate is zanidatamab, a bispecific antibody that targets two distinct domains of the human epidermal growth factor receptor 2 (HER2). Its product candidate ZW49, combines the design of zanidatamab with its ZymeLink ADC platform, comprised of its cytotoxin and cleavable linker. The firm operates through a number of platforms, including Azymetric, ZymeLink, EFECT and ProTECT. Its Azymetric is a bispecific platform that enables therapeutic antibodies to simultaneously bind multiple distinct locations on a target or to multiple targets. The Company’s ZymeLink is an antibody-drug conjugate (ADC) platform comprised of cytotoxins and the linker technology used to couple these cytotoxins to tumor-targeting antibodies or proteins.
Zymeworks Inc. is a biopharmaceutical company. The company is headquartered in Middletown, Delaware and currently employs 286 full-time employees. The company went IPO on 2019-06-24. Its lead product candidate is zanidatamab, a bispecific antibody that targets two distinct domains of the human epidermal growth factor receptor 2 (HER2). Its product candidate ZW49, combines the design of zanidatamab with its ZymeLink ADC platform, comprised of its cytotoxin and cleavable linker. The firm operates through a number of platforms, including Azymetric, ZymeLink, EFECT and ProTECT. Its Azymetric is a bispecific platform that enables therapeutic antibodies to simultaneously bind multiple distinct locations on a target or to multiple targets. The Company’s ZymeLink is an antibody-drug conjugate (ADC) platform comprised of cytotoxins and the linker technology used to couple these cytotoxins to tumor-targeting antibodies or proteins.
Revenue Growth: Zymeworks' Q3 2025 revenue rose to $27.6 million from $16 million a year ago, mainly due to a $25 million milestone payment from J&J.
Narrower Net Loss: Net loss decreased to $19.6 million from $29.9 million in Q3 2024, driven largely by higher revenues.
Strong Pipeline Progress: Encouraging Phase I data for ZW191 (folate receptor alpha ADC) showed a 64% response rate in gynecological cancers and a favorable safety profile.
New Clinical Milestones: First patient dosed in Phase I trial of ZW251 for liver cancer; study actively recruiting globally.
Share Repurchase: $22.7 million of $30 million buyback program completed, reflecting management's confidence in the company's value.
Financial Position: Cash and equivalents stood at $299.4 million at quarter end, not accounting for the $25 million J&J milestone expected in Q4.
Guidance: Existing cash plus expected milestones are projected to fund operations into the second half of 2027.
Strategic Focus: Continued emphasis on R&D innovation, disciplined capital allocation, and expanding partnerships to drive shareholder value.
