Bio Rad Laboratories Inc
NYSE:BIO
Earnings Call Analysis
Q3-2023 Analysis
Bio Rad Laboratories Inc
The third quarter showed mixed results for the company, with a reported net income of $106.3 million, a significant turnaround from a loss of $162.8 million in the same quarter last year. This boost in net income is primarily due to changes in the valuation of the Sartorius holdings. Diluted earnings per share followed suit, coming in at $3.64 compared to a diluted loss per share of $5.48 for Q3 of 2022.
The company has faced a 3.5% currency-neutral revenue decline year-over-year, contrasting its previous expectations for growth. Non-GAAP operating margins decreased to 12.9% from 15.8% in Q3 of 2022, with a fall in gross margins from 55.6% to 53.9%. This dip indicates a contraction in profitability, attributed to various adjustments such as acquisition-related benefits and restructuring efforts.
Looking ahead, the financial outlook for 2023 has been adjusted to be more conservative in response to current market conditions. The estimated growth has been scaled back from a previous prediction of around 4.5% to a range between 0 to 50 basis points when excluding COVID-related sales. The revision is a combination of factors including weaker than expected biopharma performance, a shortfall in Clinical Diagnostics, and market softness, notably in China.
The company benefited from a $36.4 million gain due to the change in fair market value of equity security holdings. Interest income from investments also bumped net other income to $9.7 million. The effective tax rate increased slightly to 22.5% from 21.5% last year, influenced by an unrealized gain in equity securities, and the non-GAAP effective tax rate is also up, with a full-year estimate between 22% and 23%.
Delving into segment specifics, the Life Science Group is predicted to experience around a 12% currency-neutral revenue decline for the year, with a narrowed decline of 4% to 5% when excluding COVID-related sales. On the other hand, the Diagnostics Group's core revenue growth is expected to be around 4.5%, marginally lower than the previously forecasted 5.5%. These figures reflect a recalibration in the company's expectations in response to shifting market dynamics.
In terms of capital management, the non-GAAP gross margin forecast has been lowered to about 54%, and the projected non-GAAP operating margin has been adjusted to roughly 14.5%, down from the 16% anticipated earlier. Meanwhile, the company plans to continue its share repurchase program while engaging in prudent expense management to navigate through a period of heightened market uncertainty.
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Good afternoon, ladies and gentlemen. Thank you for standing by. Welcome to the Bio-Rad Third Quarter 2023 Financial Results Conference Call and Webcast. [Operator Instructions]. And please be advised that today's call is being recorded on Thursday, October 26, 2023. I would now like to turn the conference over to Edward Chung. Head of Investor Relations. Please go ahead.
Good afternoon, everyone. Thank you for joining us. Today, we will review the third quarter 2023 financial results and provide an update on key business trends for Bio-Rad. With me on the call today are Norman Schwartz, our Chief Executive Officer; Ilan Daskal, Executive Vice President and Chief Financial Officer; Andy Last, Executive Vice President and Chief Operating Officer; Simon May, President of the Life Science Group; and Dara Wright, President of the Clinical Diagnostics Group. Before we begin our review, I'd like to caution everyone that we will be making forward-looking statements about management's goals, plans and expectations, our future financial performance and other matters. These statements are based on assumptions and expectations of future events that are subject to risks and uncertainties. Our actual results may differ materially from these plans goals and expectations. You should not place undue reliance on these forward-looking statements, and I encourage you to review our filings with the SEC, where we discuss in detail the risk factors in our business. The company does not intend to update any forward-looking statements made during the call today. Finally, our remarks today will include references to non-GAAP financials, including net income and diluted earnings per share which are financial measures that are not defined under generally accepted accounting principles. Investors should review these reconciliations of the non-GAAP financial measures to comparable GAAP results contained in our earnings release. With that, I will now turn the call over to Andy Last, our Executive Vice President and Chief Operating Officer, to provide an update on Bio-Rad's global operations.
Many Thanks, Ed, and good afternoon to everybody, and thank you for joining us. Well, the third quarter of the year fell below our expectations. The ongoing challenges within the biopharma segment and economic constraints in China continued to drive lower Life Sciences performance in the quarter. Clinical Diagnostic sales were weaker than we forecasted impacted mainly by the softer China market conditions. We still anticipate a strong year-over-year growth with Clinical Diagnostics Group in the fourth quarter. We continue to successfully maintain focus on tight cost control and on the supply chain front, we experienced modest constraints in supply for our clinical business, which impacted Q3 sales. Backlog remains on track to meet our year-end expectations. In Q3, we experienced further reduced demand from biopharma customers for our process chromatography resins and from both biopharma and smaller biotech customers for our Life Science research projects -- products. The continued tight spending environment in this segment constrained core ddPCR sales, which were roughly flat from the year ago period. Academic and government sales for Life Sciences was strong in the Americas, but showed declines in APAC driven down by China economic and policy constraints. EMEA academic sales were roughly flat, reflecting a soft funding environment in Germany, offset by stronger performance in the other European countries. While ddPCR sales within the quarter were softer than expected as a result of biopharma spending, we remain very positive on the long-term growth outlook for the platform. During the quarter, we were encouraged by several noteworthy announcements involving ddPCR. On the clinical testing front, our QX1 platform has been selected for SMA testing for all newborns in Hong Kong. And here in the U.S., Genoscopy announced they have published the results of their pivotal CRC prevent clinical trial, reporting the highest sensitivity for detecting colorectal cancer amongst similar tests powered by our QXDx-ddPCR platform. Additionally, in the U.S., Verily won a major multiyear national wastewater testing contract from the CDC based on our QX600 platform. We see these as contributors to future growth and a strong reinforcement of the versatility and impact of the technology. As highlighted earlier, China was a continued challenging Q3 for our Life Sciences business. And unfortunately, the economic constraints have now also impacted our clinical diagnostics business which in the first half of the year has been a positive for us in this region. We have now further constrained our expectations for China for the year-end and look to 2024 before we expect to see signs of recovery. Our clinical business overall had a mixed quarter. We saw growth in demand in the U.S. and Europe as expected, which was partially offset by the softness in China. In particular, we were pleased with the continued momentum for our immunohematology and diabetes franchises in the quarter. Despite the market challenges of this year, we view our strategy framework as being very solid and our platforms and market opportunities as providing sustainable long-term growth. We continue to focus on driving and improving our execution. And with completion of a single global instance of SAP have now completed a major component of operational improvement. Looking to the end of the year, we continue to expect the biopharma and small biotech company turndown and ongoing constraints in China and Russia to impact the overall growth through our Life Sciences business, although we do expect to see sequentially improved sales in the final quarter of the year. We remain positive on the momentum and continued growth in the clinical diagnostics business although somewhat moderated by the greater market constraints in China as well as ongoing trade restrictions in Russia. Thank you. And at this point, I will now pass you to Ilan to review the financial results.
Thank you, Andy. Now I would like to review the results of the third quarter. Net sales for the third quarter of 2023 were $632.1 million which is a decline of 7.1% on a reported basis versus $680.8 million in Q3 of 2022 and a 7.9% decline on a currency-neutral basis. The third quarter year-over-year revenue decline was primarily the result of ongoing weakness in the biopharma end markets, impacting the sales of our Life Science tools and bioprocessing products. In addition, we experienced weaker demand in China as a result of the macroeconomic environment as well as the local made in China initiatives. COVID-related sales in Q3 were $300,000 versus about $17.2 million in Q3 last year. Core revenue, which excludes COVID-related sales decreased 5.5% on a currency-neutral basis. On a geographic basis, currency-neutral year-over-year core revenue decreased in Asia and Europe, partially offset by increased sales in the Americas. Sales of the Life Science Group in the third quarter of 2023 were $263.5 million compared to $317.9 million in Q3 of 2022 which is a decline of 17.1% on a reported basis and a 17.8% decline on a currency-neutral basis. Excluding COVID-related sales, the Life Science Group year-over-year currency-neutral core revenue decreased 13.7% and was primarily driven by lower sales of qPCR, process chromatography, western blotting products and about flat year-over-year ddPCR revenue. Excluding process chromatography sales, the underlying Life Science business decreased 16.7% on a currency-neutral basis versus Q3 of 2022. The Life Science Group revenue, excluding process promotography and orbit related sales, decreased 11.6% on a currency-neutral basis. On a geographic basis, Life Science year-over-year core revenue decreased in Asia and Europe, partially offset by modest increased sales in the Americas. Sales of the Clinical Diagnostics Group in the third quarter were $368.1 million compared to $361.9 million in Q3 of 2022 or growth of 1.7% on a reported basis and a 1% growth on a currency-neutral basis. Core Clinical Diagnostics year-over-year revenue, which excludes COVID-related sales increased 1.4% on a currency-neutral basis. Growth of the Clinical Diagnostics Group was primarily driven by blood typing and diabetes products as well as growth from our quality controls portfolio. On a geographic basis, the Diagnostics group posted currency-neutral year-over-year core revenue growth in the Americas and Europe, partially offset by the decline in Asia. The reported gross margin for the third quarter of 2023 was 53.1% on a GAAP basis and compares to 54.7% in Q3 of 2022. The year-over-year gross margin decline was mainly due to unfavorable product mix, lower manufacturing volumes, higher material costs and inventory reserves and was partially offset by improved logistics costs. Amortization related to prior acquisitions recorded in cost of goods sold was $4.5 million compared to $4.4 million in Q3 of 2022. Third quarter operating expenses benefited from our cost-cutting initiatives as well as a contingent consideration benefit of $18.9 million from last year's acquisition of curiosity diagnostics. SG&A expenses for Q3 of 2023 were $201.2 million or 31.8% of sales compared to $211.1 million or 31% in Q3 of 2022. The lower SG&A in the quarter included $4.1 million in contingent consideration benefit, as I mentioned earlier, as well as lower employee-related expenses. Total amortization expense related to acquisitions recorded in SG&A for the quarter was $1.6 million versus $1.8 million in Q3 of 2022. Research and development expense in the third quarter was $43.5 million or 6.9% of sales compared to $66.8 million or 9.8% of sales in Q3 of 2022. The significantly lower R&D expenses recorded in the third quarter included $14.8 million in contingent consideration benefit that I mentioned earlier as well as lower project and employee-related expenses. Q3 operating income was $90.9 million or 14.4% of sales compared to $94.6 million or 13.9% of sales in Q3 of 2022. Looking below the operating line, the change in fair market value of equity security holdings which are substantially related to Bio-Rad's ownership of Sartorius AG shares, added $36.4 million of income to the reported results. During the quarter, interest and other income resulted in net other income of $9.7 million compared to net other expense of $13 million last year, primarily driven by increased interest income from investments. The effective tax rate for the third quarter of 2023 was 22.5% compared to 21.5% in Q3 of last year. The effective tax rate this quarter was primarily affected by an unrealized gain in equity securities and the tax rate reported in Q3 of 2022 was primarily affected by an unrealized loss in equity securities. Reported net income for the third quarter was $106.3 million or $3.64 diluted earnings per share compared to a loss of $162.8 million or $5.48 diluted loss per share in Q3 of 2022. This change from last year is largely related to changes in the valuation of the Sartorius holdings. Moving on to the non-GAAP results. Looking at the results on a non-GAAP basis, we have excluded certain atypical and unique items which impacted both the gross and operating margins as well as other income. These items are detailed in the reconciliation table in the press release. Looking at the non-GAAP results for the third quarter. In cost of goods sold, we have excluded $4.5 million of amortization of purchased intangibles and a small restructuring expense. These exclusions moved the gross margin from 53.1% for the third quarter of 2023 to a non-GAAP gross margin of 53.9% versus 55.6% in Q3 of 2022. Non-GAAP SG&A in the third quarter of 2023 was 31.7% versus 30% in Q3 of 2022. In SG&A, on a non-GAAP basis, we have excluded $4.1 million of an acquisition related to the contingent consideration benefit mentioned earlier and in vitro diagnostic registration fee in Europe for previously approved products of $1.9 million, amortization of purchased intangibles of $1.6 million, and $1.3 million of restructuring-related expenses. Non-GAAP R&D in the third quarter of 2023 was 9.2% versus 9.7% in Q3 of 2022. In R&D, on a non-GAAP basis, we have excluded $14.8 million of an acquisition related to the contingent consideration benefit mentioned earlier and a small restructuring benefit. The cumulative sum of these non-GAAP adjustments result in moving the quarterly operating margin from 14.4% on a GAAP basis to 12.9% on a non-GAAP basis. This non-GAAP operating margin compares to a non-GAAP operating margin of 15.8% in Q3 of 2022. We have also excluded certain items below the operating line, which are the increase in value of the Sartorius equity securities and loan receivable holdings of $36.4 million, $2.5 million gain from the release of an escrow for an acquisition and about a $700,000 loss associated with venture investments. The non-GAAP effective tax rate for the third quarter of 2023 was 23.9% compared to 21.7% for the same period in 2022. The higher rate in 2023 was driven by geographical mix of earnings and reduced compensation-related deductions. We continue to estimate the full year non-GAAP tax rate to be between 22% and 23%. And finally, non-GAAP net income for the third quarter of 2023 was $68.1 million or $2.33 diluted earnings per share compared to $79.2 million or diluted earnings per share of $2.64 in Q3 of 2022. Moving on to the balance sheet. During the third quarter, we purchased 58,478 shares of our stock at an average share price of $364.61 for a total cost of $21.3 million. We still have nearly $480 million remaining in our Board authorized share repurchase program. and plan to continue with our opportunistic approach to buybacks as part of our capital allocation strategy. Total cash and short-term investments at the end of Q3 was $1.765 billion compared to $1.728 billion at the end of Q2 of 2023. The increase in cash and short-term investments from the second quarter was primarily due to changes in working capital. Inventory at the end of Q3 was $775.8 million, which is slightly lower than the inventory in the prior quarter. For the third quarter of 2023, net cash generated from operating activities was $97.7 million which compares to $11 million in Q3 of 2022. This increase mainly reflects changes in working capital and income tax payments. The adjusted EBITDA for the third quarter of 2023 was $112.7 million or 17.8% of sales. The adjusted EBITDA in Q3 of 2022 was $135.7 million or 19.9% of sales. Net capital expenditures for the third quarter of 2023 were $44 million, and depreciation and amortization for the third quarter was $37.3 million. Moving on to the non-GAAP guidance. Given the current market environment, we are revising our 2023 financial outlook as follows. We now expect about a 3.5% currency-neutral year-over-year revenue decline in 2023 versus a growth of about 80 basis points previously. For the full year, we estimate currency neutral year-over-year revenue growth, excluding COVID-related sales to be between 0 and 50 basis points versus about 4.5% in our prior guidance. Of the 400 to 450 basis points core revenue guide down, 50 basis points are related to the third quarter revenue shortfall of which approximately 200 basis points is related to weakness in BioPharma and remaining 50 basis points related to lower clinical Diagnostics states. The remaining 150 to 200 basis points reduction is attributed to reduce process chromatography and other BioPharma demand as well as continued softness in China. For the Life Science Group, we expect about a 12% currency-neutral revenue decline for 2023 and when excluding COVID related sales, the Life Science Group currency-neutral revenue decline is projected to be between 4% and 5%. Excluding COVID and process chromatography related sales, Life Science Group revenue is expected to decline between 2% and 3%. For the Diagnostics group, while we remain encouraged with the overall demand we are now guiding core revenue growth to be about 4.5% versus 5.5% previously. Full year non-GAAP gross margin is now projected to be about 54% and versus about 54.5% previously, reflecting our updated expectation of shift in product mix and volume. We now project full year non-GAAP operating margin to be about 14.5% versus approximately 16% in our prior guidance. as we continue to carefully manage discretionary expenses. And full year adjusted EBITDA margin is expected to be between 20% and 20.5%. We versus about 21.5% in our prior guidance. And now I'll turn the call over to Norman for a few remarks. Norman?
Thank you, Ilan. So I guess I just wanted to take a minute here to really to recognize Ilan and his contributions over the last several years. As part of our transformation, Ilan has been a very valued member of the team. kind of working to improve financial planning and reporting processes as well as to enhance the company's external profile with the financial community. I think we all very much appreciate his guidance and contributions which do position us well for our continuing transformation. As you might imagine, we have initiated a search for a successor. And in the meantime, we have a strong, capable team who can manage very well in the interim. So maybe while I have the floor or maybe a closing comment about this year. Certainly, it's not unfolded the way we or many of our peers first envisioned it. kind of coming out of the pandemic, I think it has been challenging to predict the pace of recovery or market normalization really all exacerbated by inflation we've not seen in 20 years, geopolitical events and, of course, the biopharma disruption. I think if I think about it a little bit. I think what we can be confident of is that our markets are buoyant. And I feel the outlook is positive. There could always be a few more bumps in the road in the near term, but I do feel the company is really is well positioned to navigate what might come our way. And just maybe to reemphasize a point that Andy made, longer term, our strategy and vision for the future really has not changed. With that, operator, I think we'll open the line up to questions.
And ladies and gentlemen, we will now begin the question-and-answer session. [Operator Instructions]. Your first question comes from the line of Brandon Couillard from Jefferies.
I am sure this is another question for Andy or Ilan, but the magnitude of the guidance we said in Life Sciences, relative to where you started the year, is the most dramatic of any of your peers by far. [ There seem ] to be such an inability to accurately forecast the business and demand trends? And how do we assess whether this is, in fact, a market dynamic as opposed to potential share losses?
Could you just say the very last piece again, Brandon? I didn't catch your very last few words.
How do we assess whether this is, in fact, a market dynamic versus potential share losses in Life Science.
Okay. Look, I think that we came out of 2022 with really good trajectory. And the effects that some companies had seen particularly in bioprocessing, we're not showing up for us. And that -- I think that's something that we communicated at the end of the first quarter that, that was a surprise. And it took a while within 2023 for those effects to really roll out into our funnel and start to experience the deferred orders being pushed out. But then the other factor that no one anticipated and which was meaningful for us was the Silicon Valley Bank collapse and the knock-on effects of that, which really impacted the spending profile of the smaller biotech companies, and we had significant trajectory in the smaller biotechs for, in particular, our Droplet Digital PCR platform, which also had some halo effect around it. So I think it took a couple of quarters for those effects to really materialize for us because our profile is a little different to some of the other players. So that's how I view it. And then, of course, since then, spending has not improved. The order pushouts have continued and it's very difficult to gauge the true inflection point right now, and I think that's probably a message is coming across broadly from other players in the category as well.
This is Simon. Maybe I'll just add to that as well because as we look at our funnels and we look at our win-loss ratios across the portfolio, whether you're talking about Western block or gene expression or digital PCR or our bioprocess business, we really don't see any significant shifts there. I mean, obviously, the conditions in China in BioPharma have really deteriorated. But the feedback that we consistently get from the field is that there's still a high level of interest in the products. The products that we've launched to be really well received. And again, the funnel dynamics in terms of win-loss ratios are not seeing any significant shifts. So we really do believe that this is a bunch of transient effects that are compounding and it's making for a very difficult year but I don't think there are any macro shifts in our competitive positioning in Life Sciences.
Okay. Ilan, I think the revised guide implies 4Q revenue steps up to about $700 million, I believe is usually seasonally very strong for [indiscernible], but this isn't a normal environment either. So how derisked is that revenue outlook? What are some of the variables that can swing that target up or down as you're keeping in mind?
So it's Andy. The variables that might swing that, I think they're the same that we're -- the variables would really be the same that we're experiencing just a little bit more acute if China gets definitively worse than the trajectory it's on, for example, that [indiscernible] academia really pulled back some spending that could have an effect we're not expecting a Q4 budget flush this year. That's not in our thinking. If that materializes, that's good news, but we're not planning on that. I think other than that, I don't think we see anything that may be meaningful that we could predict.
And Brandon, I will add to the inputs that Andy just mentioned. Generally speaking, we have not deviated from our approach of kind of coming up with the realistic what we see in front of us in terms of the 4% guidance. So I don't know that we are underestimating or overestimating our projections. And definitely, the fourth quarter this time around is an unusual circumstance in addition to the macroeconomic kind of environment to end this kind of inputs maybe the China environment today. I mean, I think it's going to continue well into the end of the year. So the smaller biotechnology companies environment in terms of the funding environment are not expected to improve in our mind through the end of this year. So I agree with you, historically, traditionally, the fourth quarter used to be a stronger seasonality kind of quarter for us. That is not the case this time around.
Okay. Last one, and then I'll jump back in the queue. Andy, given you and Ilan started at Bio-Rad around the same time, you've worked very closely together. You've both been instrumental to Bio-Rad's transformation last 4 years or so. in light of his departure, I think investors would like to know, are you happy with the operational direction of the company? Are you adequately incentivized to stay the course? Or do you have an eye to retirement anytime soon?
Yes, Brandon, thanks. So first, can I just say I'm really sad to see Ilan move on. And you're right, we have worked extremely closely. He and I are in each other's offices virtually every day. So it's been a really good journey. I want to thank Ilan for that. [indiscernible] But my point of view right now is we started this transition. it's not finished. And the focus really is on the transformation of the company and executing against the strategy framework, which I firmly believe has the potential to increase operating performance for the company moving forward.
Your next question comes from the line of Patrick Donnelly from Citi. .
Maybe another one on the 4Q ramp, but on the margin side, a pretty meaningful step-up from whether it's sequential or the rest of the prior part of the year. Can you just talk about the moving pieces to get to that implied margin? I think it's 16.5%, 17% type margin in 4Q, yes, just a path to get there and get people comfortable that that's a realistic number.
Sure. Patrick, this is Ilan. I'll start and Andy can chime in. But obviously, on the top line, we baked in kind of the updated mix with the software life science. And overall, I mean, on the operating expenses, we plan to continue some of those initiatives that we have been working on. And already in the third quarter, you can see that the operating expenses came in lower on a dollar basis. So we continue to work on additional initiatives going into the fourth quarter. And again, overall, for the bottom line, I mean, we feel it is a realistic projection here.
I may only add we're still focused on keeping our operating cost structure as tight as possible. The volume and mix will have a decent flow-through in the fourth quarter operating margin.
Okay. And then maybe on China, if you could just talk about that market a little bit surprising to see the diagnostics piece softer as well. Can you just talk about what you're seeing? Is it various policies over there that's impacting things? It would be helpful just to get a little more discussion there.
Okay. So the policies, I mean, are clearly impacting both Life Science and the Diagnostics side of the business. And they have -- they're made in China for China. There's the anticorruption, there's volume-based pricing, and then you layer on top of that recession. And the government, I think, that is generally struggling to find the right way to stimulate the market. You can add in an extra effect of capital markets soft for biopharma, which was a focus for us for expansion and growth of our -- those pieces of our portfolio. They all have varying impacts to both sides of the business. And it's just been a really tough right through China, and there's just no current clear reason to think that it's going to improve in Q4. And on the Clinical side, it just created a softer pull for our products in China and in the quarter. And we still have had a little bit of backlog on our clinical business as we called out, which by the end of this year, we should be roughly where we expect to be we may finish with a very slightly elevated backlog on clinical products at the end of the year, but we're pretty much on track relatively speaking for that.
Okay. On the diagnostics side, is it more the instrumentation. Obviously, the VBP stuff comes up quite often with all diagnostic players. Are you guys seeing anything on that front yet?
What was the question?
The volume-based pricing. Sorry, we were just having difficulty here. Dara, do you want to comment on VBP?
Sure. It's starting to impact how we navigate tender requirements. So I think how that's translating to reality is things are a little bit slower as we're navigating how best to position for new deal considerations. But value-based pricing, it has historically been applied to other sectors, but in a couple of provinces we're starting to see it reach into -- [ to IBD ]. So I think right now, it's just sort of impacting sort of forward-looking risk. And then as Andy said, we're still working through some supply chain fulfillment challenges in backlog, which we're waited a bit towards that region as well. And we're working through that and have line of sight for a really solid Q4 landing.
Okay. And maybe last one, just on the PCR side. You guys called out, I think, qPCR weakness, it seemed like ddPCR step down as well. Can you just talk about what you're seeing in that market? Is it just broader slowdown? Is it specific pockets there would be helpful.
I think again, it's a compounding the issues that we've already touched on here. So we've obviously got a fairly significant qPCR, digital PCR footprint in BioPharma. And again, the slowdown in early biotechs. We've seen a continuation of layoffs and project deferrals, that's impacted the business. We've got the COVID compare. We've got all the challenges in China that we've already talked about. And I think on top of everything else, there's kind of a club of systems out there in the market that were placed in the pandemic, and there's a bit of free capacity out there. So you roll all of these things together. Again, we refreshed our qPCR platform over the last couple of years. And again, the feedback that we get from out in the field is really positive in terms of how these products are being received in the market, but this compounding of market conditions right now is what's adding up to its environment.
May I just add one extra comment. You look for the silver lining on occasion and the customer demand in that -- in small Biotech BioPharma, the desire to take in digital PCR, in particular, remain very strong. What we're actually experiencing is just the deferral of when they're going to make the purchase because they're constrained on kind of cash expenditure and some other changes going on structurally on the comp program focus. So the demand side remains very encouraging.
Your next question comes from the line of Jack Meehan from Nephron.
So just wanted to talk about how the quarter played out here. So revenue was about 8% below the [indiscernible]. Can you just talk about kind of the pacing of the quarter. Was most of the pressure you saw in September? And is it possible, are there any orders that slipped into 4Q for any reason?
I think Jack -- this is Ilan Daskal. The way to think about it, I think we saw it throughout the quarter, but it accelerated towards the end of the quarter. So the pace was kind of decline was stronger towards the end of the quarter. But what throughout the quarter, it started to get weaker and weaker, but definitely, it accelerated towards the end.
Okay. And Norman, I know you mentioned in your comments, there's potential for maybe a couple more bumps in the road along the way. I think there's a debate amongst tools investors around further through the cutting cycle? Or could there be kind of new risks ahead because of some of the changes in the funding environment for customers? Just curious like maybe like what you're seeing through October? Do you -- I guess, like kind of what was the thinking that went behind the fourth quarter guide that you've built here?
Well, I think certainly, in terms of the fourth quarter guide, we look carefully at kind of the order book in the funnel, the sales funnel, kind of accumulating as much data as we can to get the best assessment of where we think we'll land for the year. When I think about bumps in the road, I think about the -- I think there were a lot of people that kind of thought the pandemic is over and everything will be back to normal next week. And I think we're seeing a continuation of that with some of this kind of biopharma meltdown and the readjustments that are being made in some of these programs. It just -- I think we just have to be careful about calling the end and saying, it's always possible that there's something else that might bubble up.
Understood. Okay. And then on the income statement, you previously talked about kind of OpEx reductions. I was looking at the SG&A line kind of on a non-GAAP basis, it actually increased a little bit sequentially, and that was despite kind of revenue declining sequentially. So I was just wondering if you could talk about what happened in SG&A in the quarter? And like is there room to like pull more cost out given the lower top line?
So usually, where you see it was a minor kind of step-up, Jack. Usually, on the fourth quarter, we see a much higher kind of step-up in SG&A which this time around, actually more of the initiatives that we have been working on will kick in on the -- in the fourth quarter. So we don't anticipate the traditional step up in the fourth quarter. For the third quarter, it wasn't that material.
Your next question comes from the line of Tim Daley from Wells Fargo.
So first on the process chromatography business. So I think you were previously expecting down mid-single to high single decline. With the update today, I'm getting to 13% down or so for the year. But even with that, that implies a pretty significant step up in the fourth quarter. I think almost like 80% sequential dollar increase from 3Q to 4Q. So first off, are these numbers that I'm kind of getting to in the right ballpark? And then secondly, can you help us understand the visibility confidence that you have to kind of get that big sequential step up, especially given the commentary around a slower or lower than typical seasonality for this year-end?
Yes, this is Andy. So yes, I think maybe it's kind of some of the math might be a little off there. I think the process chrome overall it's going to end up at a lower number in kind of the guidance implication there. And it's kind of like mid-teens and so I don't think we're seeing a meaningful step-up in process chrome in Q4. But yes, I think that's really probably just a bit of math there, it's slightly higher.
All right. Got it. That's helpful. And then, Andy, can you -- the supply chain impacts weighing on the third quarter Diagnostics revenues, can you just provide some details on like what is that, how big the impact was in the quarter? And if you expect those delayed revenues to be fully recuperated in fourth quarter?
Yes. So essentially, we -- obviously, we've been communicating our supply chain challenge on the clinical side because various impacts of COVID plus we moved our plants from France to Singapore. We're catching up quickly, but it's sometimes difficult to get the pacing of that right. So if you get a bit of delay, you also get a bit of pull-through, consumable pull-through delay as well. And so that faced a bit into our Q3. But we are looking at a pretty strong Q4, and we have good line of sight now. Our plant in Singapore is really cranking. We've done a lot of work leading out the workflows there. And so we're going to get the benefit of that in Q4 and also get some pull-through effect. So Q3 just ended up being softer as a result overall.
All right. And then final one here for Norman. With the '23 guidance now 400 basis points lower, that midterm CAGR for 2025, the guidance updated in May now has an incremental 100 basis points or so steeper, I guess, headwinds in front of it. So given the current environment, how are you evaluating the 2025 target? Or is this something that maybe will wait until a new CFO is in the seat to put their own fingerprints on if you will?
So Tim, this is Ilan, I will chime in and then Norman probably will have some additional color. But already in the prior quarter, we communicated that the 2025 targets from our perspective is kind of in a holding pattern. We would like to get more insight and visibility going into 2024 in order to shape our thinking about the 2025 targets. So probably in the next kind of earnings call early next year, when we have the 2024 kind of guidance in front of us, the 2025 numbers, we'll know how to think about it and to see whether the reason impact and what magnitude [ it's around].
I think that covers it pretty well.
Your next question comes from the line of Conor McNamara from RBC Capital.
Just without getting into 2024 guidance, just how should we think about 2024 in general? And just which headwinds that you called out in this quarter likely to persist in 2024 and which are likely to end by the end of this year?
Conor, this is Ilan. So I can start with obviously various aspects that are associated with the macroeconomic I'm not sure personally that China will recover like in a few weeks. So that may take a little bit longer. The funding environment, which is obviously indirectly linked to the treasury yield is here to stay. The inflationary environment is here to stay for a while. So there does and probably will continue for a while to have some impact on the smaller biotechnology companies funding. And the way they think about the pace of their spend. So these are definitely areas that we want to kind of think about it to think about and then not to mention the geopolitical [indiscernible] that is getting kind of to probably a new level that we have not experienced before. So there are multiple fronts there that -- and when you think about Europe, I mean, overall, for us, Europe, generally speaking, is doing okay for us. But when you think about the macroeconomic, Germany is probably already in a recession. So it's going to be interesting. I mean specifically that domestically, we're going into an election year domestically. So we'll have to wait and see how everything will shape up. But it doesn't have to do anything with our own kind of organic initiatives, products, new products, the end markets that are not disappearing, they're not going anywhere. So it's only from my perspective, only a timing issue.
Okay. Great. And just following up to Patrick's question about PCR. Can you just talk about ddPCR, specifically because that slowdown was worse than any of your other business units. So how do we -- can you give investors some framework to think about how that -- how we can get comfort that that's definitely a market environment and not competitive pressure because there have been some competitors out there making some noise. So we just want to make sure that you still feel good about your market position there in ddPCR?
I still think we feel good about the position. I mean, we've made no secret of the fact that the competitive landscape is intensified. And as we reflect on Q3, I think as we called out in the scripts, we had a couple of really notable wins there that we think are going to help continue to position us well for the future. I think what we really saw in Q3, again, is an exacerbation of these biopharma impacts. We have put secular strength in the early biotech sector. And I think what we saw in Q3 was a cumulative impact of these deferred projects and layoffs in the continuing extremely tight budget environment. Once again, we're seeing a lot of interest in the products, but the money is just not flowing. We continue to see healthy adoption and really strong acceptance of our QX600 platform. So as we look to the future, if we all believe that these impacts in BioPharma transient and when we emerge from it, we think we're going to be in a really strong position. And then, of course, we've got competitors who are playing more in the lower end segments, and we plan to enter there with the QX Continuum platform in 2024. So for sure, the competitive pressure is intensifying, but I think we've got compelling responses and where we've got leading positions in these segments will continue to do well as and when these markets recover.
Great. And just a quick follow-up on pricing. And I guess this is across everything in Life Sciences. What's the pricing environment like? And how should we think about that going forward?
Yes. I think that the environment is still inflationary. As you probably appreciate, on the clinical side, tender-driven business, you can only take very modest and periodic price increases. And we do that when we get that opportunity. On Life Science, the there is still inflationary effect and we will still look to try and take modest price increases as we move forward to help offset our inflationary pressures that we're receiving. And we expect to do -- we've done that this year. We expect to do that next year. And I think in the quarter, we probably got just over 1 point of price, 1.5 points of price on a net basis and think that, that should at least be a [ floor ].
We've seen a mix impact there we process [ Chrome ] as well.
Okay. And just a final question. This for Norm. Just given the recent selloff in the space and specifically in your stock, how does that change your acquisition strategy, if at all? And would you still considering would you still consider issuing equity to pursue an acquisition target in this environment?
So I think that kind of in light of the recent stock dislocation, I think we will very much consider continuing our share repurchases as part of our capital allocation strategy and obviously, at this point, not such a good currency for M&A. I think, in fact, while we do continue to kind of look at opportunities, I think it's probably fair to say that more of our focus over the next several quarters will be centered around kind of navigating our markets and our continued operational transformation.
There are no further questions at this time. I would like to turn it back to Edward Chung for further remarks.
Thank you for joining today's call. As always, we appreciate your interest, and we look forward to connecting soon. Thanks, operator.
Thank you. And ladies and gentlemen, this concludes today's conference call. Thank you for participating. You may now disconnect.