Summit Therapeutics Inc
NASDAQ:SMMT

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Summit Therapeutics Inc Logo
Summit Therapeutics Inc
NASDAQ:SMMT
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Price: 17.57 USD -2.33% Market Closed
Market Cap: 13.1B USD

Summit Therapeutics Inc
Investor Relations

Summit Therapeutics Inc., headquartered in Cambridge, Massachusetts, has carved a niche in the biopharmaceutical landscape with its focus on addressing serious unmet medical needs, primarily through the development of innovative antibiotics and therapies. The company gained significant attention with its efforts to combat antibiotic resistance, a global health threat. Their flagship endeavor, Ridinilazole, is an antibiotic designed to treat C. difficile infections, a prevalent and often severe bacterial infection affecting the gut. The company's proposition is simple yet impactful: develop effective treatments that not only address infections but also potentially reduce recurrence, thereby offering a better therapeutic alternative to existing solutions.

Summit's business model is built around advancing their drug pipeline through rigorous clinical trials, securing regulatory approvals, and ultimately achieving commercialization either independently or through strategic partnerships. The partnerships are critical, as they allow Summit to leverage the expertise and market reach of larger pharmaceutical companies. Additionally, these alliances provide financial backing, helping offset the costly nature of drug development. Revenue is primarily driven from these collaborations through milestone payments and eventual product royalties, once their therapies hit the market. This strategic approach allows Summit to focus its resources on research and development while aligning with partners to navigate the complexities of bringing new therapies to patients globally.

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Last Earnings Call
Fiscal Period
Q3 2025
Call Date
Oct 20, 2025
AI Summary
Q3 2025

Strong Clinical Results: The HARMONi-6 Phase III trial showed ivonescimab plus chemotherapy delivered a significant progression-free survival benefit in advanced squamous non-small cell lung cancer, with a hazard ratio of 0.60 and median PFS of 11.14 months versus 6.90 months for the control arm.

Expansion of Pipeline: Summit expanded its Phase III clinical program to include a new global trial (HARMONi-GI3) in first-line unresectable metastatic colorectal cancer, bringing the total to 14 planned or ongoing Phase III studies.

Regulatory Momentum: Summit intends to submit a BLA for ivonescimab plus chemotherapy in the US in Q4 2025, based on HARMONi results, and is working closely with the FDA.

Financial Position: Summit ended Q3 2025 with $238.6 million in cash, and management noted an ATM facility and interest in additional funding to support expanded trials.

Enrollment Ahead of Plan: Enrollment for HARMONi-3 squamous and non-squamous cohorts is ahead of schedule, with over 80% of the squamous cohort enrolled and completion expected in early 2026.

Key Financials
Cash Position
$238.6 million
Operating Expenses
$234.2 million
Non-GAAP Operating Expenses
$103.4 million
Patients Enrolled in HARMONi-6
532
Patients to be Enrolled in HARMONi-3
1,600
Median Progression-Free Survival (ivonescimab arm, HARMONi-6)
11.14 months
Median Progression-Free Survival (control arm, HARMONi-6)
6.90 months
Hazard Ratio for Progression-Free Survival (HARMONi-6)
0.60
P value for Progression-Free Survival (HARMONi-6)
<0.0001
Earnings Call Recording
Other Earnings Calls

Management

Mr. Robert W. Duggan
Co-CEO & Executive Chairman
No Bio Available
Dr. Mahkam Zanganeh D.D.S., M.B.A.
Co-CEO, President & Director
No Bio Available
Mr. Manmeet Singh Soni CPA
COO, CFO & Director
No Bio Available
Prof. Dame Kay Davies DBE, FRS CBE
Co-Founder, Chairman of Scientific Advisory Board and Scientific Advisor
No Bio Available
Mr. Bhaskar Anand
Chief Accounting Officer & Head of Finance
No Bio Available
Ms. Divya Chari
Head of Global Clinical Operations
No Bio Available
Mr. Dave Gancarz
Chief Business & Strategy Officer
No Bio Available
Dr. Betty Y. Chang Ph.D.
Head of Research, Oncology & Inflammation
No Bio Available
Dr. Fong Clow
Chief Biometrics Officer
No Bio Available
Ms. Shelley D. Spray
Chief Education & Brand Officer
No Bio Available

Contacts

Address
MASSACHUSETTS
Cambridge
One Broadway, 14Th Floor
Contacts
+16175147149.0
www.summittxinc.com